Selection of materials for a nuclear rocket engine

Selection of materials which will be used in the construct of a nuclear reactor for a space rocket

An Exploratory Analysis Of A Time Synchronization Protocol For UAS

This dissertation provides a numerical analysis of a Receiver Only Synchronization (ROS) protocol which is proposed for use by Unmanned Aircraft Systems (UAS) in Beyond Visual Line of Sight (BVLOS) operations. The use of ROS protocols could reinforce current technologies that enable transmission over 5G cell networks, decreasing latency issues and enabling the incorporation of an increased number of UAS to the network, without loss of accuracy. A minimum squared error (MSE)-based accuracy of clock offset and clock skew estimations was obtained using the number of iterations and number of observations as independent parameters. Although the model converged after only four iterations, the number of observations needed was considerably large, of no less than about 250. The noise, introduced in the system through the first residual, the correlation parameter and the disturbance terms, was assumed to be autocorrelated. Previous studies suggested that correlated noise might be typical in multipath scenarios, or in case of damaged antennas. Four noise distributions: gaussian, exponential, gamma and Weibull were considered. Each of them is adapted to different noise sources in the OSI model. Dispersion of results in the first case, the only case with zero mean, was checked against the Cramér-Rao Bound (CRB) limit. Results confirmed that the scheme proposed was fully efficient. Moreover, results with the other three cases were less promising, thus demonstrating that only zero mean distributions could deliver good results. This fact would limit the proposed scheme application in multipath scenarios, where echoes of previous signals may reach the receiver at delayed times. In the second part, a wake/sleep scheme was imposed on the model, concluding that for wake/sleep ratios below 92/08 results were not accurate at p=.05 level. The study also evaluated the impact of noise levels in the time domain and showed that above -2dB in time a substantial contribution of error terms disturbed the initial estimations significantly. The tests were performed in Matlab®. Based on the results, three venues confirming the assumptions made were proposed for future work. Some final reflections on the use of 5G in aviation brought the present dissertation to a close

Assessing Cultural Drivers of Safety Resilience in a Collegiate Aviation Program

Organizational safety resilience is a key factor in sustaining an effective safety management system (SMS) in high-reliability organizations (HROs) such as aviation. Extant research advocates for monitoring, assessing and continuously improving safety in an organization that has a fully-functional SMS. Safety resilience provides a buffer against vulnerabilities. Extant research also suggests a paucity in terms of a measurement framework for organizational safety resilience in collegiate aviation operations. A quantitative approach using Reason’s safety resilience concept (Reason, 2011) is used to assess organizational safety resilience in a collegiate aviation program with an active conformance SMS accepted by the FAA. A sample of 516research participants responded to an online survey instrument derived from Reason (2011). Structural Equation Model (SEM)/Path Analysis (PA) techniques are used to assess models that measure the strength of relationships between three cultural drivers (Commitment, Cognizance, Competence)of safety and safety resilience. There were strong significant relationships between these cultural drivers and safety resilience. Path analysis suggests that Commitment significantly mediates the path between Cognizance and Competence and highlights its important role in sustaining safety competencies. There were significant differences in the perceptions of safety resilience among top-level leadership, flight operations and ground operations. Flight operations and ground operations had higher mean scores on safety resilience than top-level leadership. Study provides a validated model of safety resilience that is essential for SMS improvements in collegiate aviation programs. Future studies will utilize this safety resilience model to assess other collegiate aviation programs in various phases of SMS implementation, airlines, and air traffic control operations

Assessing the relationship between organizational management factors and a resilient safety culture in a collegiate aviation program with Safety Management Systems (SMS)

Extant research advocates for assessing and continuously improving resilient safety culture in high-reliability organizations (HROs) such as aviation that has a fully functional Safety Management Systems (SMS). Perceptions on the relationship between four (4) organizational management factors (Principles, Policy, Procedures, Practices) and resilient safety culture in a collegiate aviation program was assessed using an online survey instrument drafted using Reason (2011) concept on safety resilience. Sample was drawn from aviation students, flight instructors, faculty and administrators. Structural Equation Model (SEM) and Causal Path Analysis (CPA) techniques were used to assess conceptual models. Results suggest good reliability and construct validity for survey instrument. All the measurement models had acceptable fit based on various goodness-of-fit indices. The results suggest all four management factors had significant predictive relationship with resilient safety culture. Practices had the weakest predictive relationship and Policy had the highest. Procedures strongly mediated path between Policies and Practices and there was no significant causal relationship between Principles and Practices. Results suggest that more focus should be placed on resilient safety practices in the collegiate aviation program. Significant benefit of this study is the validation of an instrument that explores the relationship between resilient safety culture and organizational management factors and adds to literature on resilient safety culture in collegiate aviation programs. Future studies using this survey instrument and models in other collegiate aviation programs, airlines and airports are highly recommended

Original research: Second IVIg course in Guillain-Barr\ue9 syndrome with poor prognosis: the non-randomised ISID study.

OBJECTIVE: To compare disease course in patients with Guillain-Barr\ue9 syndrome (GBS) with a poor prognosis who were treated with one or with two intravenous immunoglobulin (IVIg) courses. METHODS: From the International GBS Outcome Study, we selected patients whose modified Erasmus GBS Outcome Score at week 1 predicted a poor prognosis. We compared those treated with one IVIg course to those treated with two IVIg courses. The primary endpoint, the GBS disability scale at 4 weeks, was assessed with multivariable ordinal regression. RESULTS: Of 237 eligible patients, 199 patients received a single IVIg course. Twenty patients received an 'early' second IVIg course (1-2 weeks after start of the first IVIg course) and 18 patients a 'late' second IVIg course (2-4 weeks after start of IVIg). At baseline and 1\u2009week, those receiving two IVIg courses were more disabled than those receiving one course. Compared with the one course group, the adjusted OR for a better GBS disability score at 4 weeks was 0.70 (95%CI 0.16 to 3.04) for the early group and 0.66 (95%CI 0.18 to 2.50) for the late group. The secondary endpoints were not in favour of a second IVIg course. CONCLUSIONS: This observational study did not show better outcomes after a second IVIg course in GBS with poor prognosis. The study was limited by small numbers and baseline imbalances. Lack of improvement was likely an incentive to start a second IVIg course. A prospective randomised trial is needed to evaluate whether a second IVIg course improves outcome in GBS

International Guillain-Barré syndrome outcome study: protocol of a prospective observational cohort study on clinical and biological predictors of disease course and outcome in Guillain-Barré syndrome

Guillain-Barré syndrome (GBS) is an acute polyradiculoneuropathy with a highly variable clinical presentation, course, and outcome. The factors that determine the clinical variation of GBS are poorly understood which complicates the care and treatment of individual patients. The protocol of the ongoing International GBS Outcome Study (IGOS), a prospective, observational, multicenter cohort study that aims to identify the clinical and biological determinants and predictors of disease onset, subtype, course and outcome of GBS is presented here. Patients fulfilling the diagnostic criteria for GBS, regardless of age, disease severity, variant forms, or treatment, can participate if included within 2 weeks after onset of weakness. Information about demography, preceding infections, clinical features, diagnostic findings, treatment, course, and outcome is collected. In addition, cerebrospinal fluid and serial blood samples for serum and DNA is collected at standard time points. The original aim was to include at least 1,000 patients with a follow-up of 1-3 years. Data are collected via a web-based data entry system and stored anonymously. IGOS started in May 2012 and by January 2017 included more than 1,400 participants from 143 active centers in 19 countries across 5 continents. The IGOS data/biobank is available for research projects conducted by expertise groups focusing on specific topics including epidemiology, diagnostic criteria, clinimetrics, electrophysiology, antecedent events, antibodies, genetics, prognostic modeling, treatment effects, and long-term outcome of GBS. The IGOS will help to standardize the international collection of data and biosamples for future research of GBS

International Guillain-Barré Syndrome Outcome Study: protocol of a prospective observational cohort study on clinical and biological predictors of disease course and outcome in Guillain-Barré syndrome

Guillain-Barré syndrome (GBS) is an acute polyradiculoneuropathy with a highly variable clinical presentation, course, and outcome. The factors that determine the clinical variation of GBS are poorly understood which complicates the care and treatment of individual patients. The protocol of the ongoing International GBS Outcome Study (IGOS), a prospective, observational, multicenter cohort study that aims to identify the clinical and biological determinants and predictors of disease onset, subtype, course and outcome of GBS is presented here. Patients fulfilling the diagnostic criteria for GBS, regardless of age, disease severity, variant forms, or treatment, can participate if included within 2 weeks after onset of weakness. Information about demography, preceding infections, clinical features, diagnostic findings, treatment, course, and outcome is collected. In addition, cerebrospinal fluid and serial blood samples for serum and DNA is collected at standard time points. The original aim was to include at least 1,000 patients with a follow-up of 1–3 years. Data are collected via a web-based data entry system and stored anonymously. IGOS started in May 2012 and by January 2017 included more than 1,400 participants from 143 active centers in 19 countries across 5 continents. The IGOS data/biobank is available for research projects conducted by expertise groups focusing on specific topics including epidemiology, diagnostic criteria, clinimetrics, electrophysiology, antecedent events, antibodies, genetics, prognostic modeling, treatment effects, and long-term outcome of GBS. The IGOS will help to standardize the international collection of data and biosamples for future research of GBS. © 2017 Peripheral Nerve Societ

International Guillain-Barré Syndrome Outcome Study: protocol of a prospective observational cohort study on clinical and biological predictors of disease course and outcome in Guillain-Barré syndrome

Guillain-Barré syndrome (GBS) is an acute polyradiculoneuropathy with a highly variable clinical presentation, course, and outcome. The factors that determine the clinical variation of GBS are poorly understood which complicates the care and treatment of individual patients. The protocol of the ongoing International GBS Outcome Study (IGOS), a prospective, observational, multicenter cohort study that aims to identify the clinical and biological determinants and predictors of disease onset, subtype, course and outcome of GBS is presented here. Patients fulfilling the diagnostic criteria for GBS, regardless of age, disease severity, variant forms, or treatment, can participate if included within 2 weeks after onset of weakness. Information about demography, preceding infections, clinical features, diagnostic findings, treatment, course, and outcome is collected. In addition, cerebrospinal fluid and serial blood samples for serum and DNA is collected at standard time points. The original aim was to include at least 1,000 patients with a follow-up of 1–3 years. Data are collected via a web-based data entry system and stored anonymously. IGOS started in May 2012 and by January 2017 included more than 1,400 participants from 143 active centers in 19 countries across 5 continents. The IGOS data/biobank is available for research projects conducted by expertise groups focusing on specific topics including epidemiology, diagnostic criteria, clinimetrics, electrophysiology, antecedent events, antibodies, genetics, prognostic modeling, treatment effects, and long-term outcome of GBS. The IGOS will help to standardize the international collection of data and biosamples for future research of GBS

International Guillain-Barré Syndrome Outcome Study: protocol of a prospective observational cohort study on clinical and biological predictors of disease course and outcome in Guillain-Barré syndrome

Guillain-Barré syndrome (GBS) is an acute polyradiculoneuropathy with a highly variable clinical presentation, course, and outcome. The factors that determine the clinical variation of GBS are poorly understood which complicates the care and treatment of individual patients. The protocol of the ongoing International GBS Outcome Study (IGOS), a prospective, observational, multicenter cohort study that aims to identify the clinical and biological determinants and predictors of disease onset, subtype, course and outcome of GBS is presented here. Patients fulfilling the diagnostic criteria for GBS, regardless of age, disease severity, variant forms, or treatment, can participate if included within 2 weeks after onset of weakness. Information about demography, preceding infections, clinical features, diagnostic findings, treatment, course, and outcome is collected. In addition, cerebrospinal fluid and serial blood samples for serum and DNA is collected at standard time points. The original aim was to include at least 1,000 patients with a follow-up of 1–3 years. Data are collected via a web-based data entry system and stored anonymously. IGOS started in May 2012 and by January 2017 included more than 1,400 participants from 143 active centers in 19 countries across 5 continents. The IGOS data/biobank is available for research projects conducted by expertise groups focusing on specific topics including epidemiology, diagnostic criteria, clinimetrics, electrophysiology, antecedent events, antibodies, genetics, prognostic modeling, treatment effects, and long-term outcome of GBS. The IGOS will help to standardize the international collection of data and biosamples for future research of GBS